Peptides studied in antimicrobial, membrane-permeabilization and cytokine-pathway assays. These are the sequences used in minimum-inhibitory-concentration work, membrane-disruption models and toll-like receptor binding studies.
LL-37 is the C-terminal fragment of human cathelicidin hCAP-18, an amphipathic alpha-helical peptide studied for direct membrane permeabilization against bacterial model membranes and for its interaction with innate-immune signaling pathways. Thymosin Alpha-1 is a 28-amino-acid N-terminally acetylated peptide used in toll-like receptor binding and T-cell culture assays. ARA 290 is an 11-amino-acid sequence derived from the helix B region of erythropoietin, studied for binding at the innate repair receptor (IRR) rather than at the classical EPO receptor – a distinction that is the entire point of the molecule in a research context.
Cationic amphipathic peptides such as LL-37 adsorb to plastic and are usually handled in low-bind tubes at working concentration. Purity is verified by RP-HPLC. All items are supplied as laboratory reference materials for in-vitro research use only.
