What CJC-1295 (no DAC) is
CJC-1295 without DAC is a 29-residue GHRH-derived peptide amide, better described chemically as modified GRF(1-29). It starts from the first 29 residues of human growth hormone-releasing hormone and changes four of them: D-alanine at position 2, glutamine at position 8, alanine at position 15 and leucine at position 27. The same molecule is sold as “Mod GRF 1-29”, “CJC-1295 no DAC” and “CJC-1295 without DAC”; all three labels mean this one sequence.
Its closest catalog neighbors are easy to mix up. Sermorelin is the identical frame with none of the four substitutions. CJC-1295 DAC is this exact chain plus a thirtieth residue, a lysine carrying a maleimidopropionyl group, which adds roughly 280 Da. This vial contains no DAC moiety, so its expected mass sits near 3368 rather than above 3600.
CJC-1295 5mg specification
| Catalog name | CJC-1295 (no DAC), modified GRF(1-29) |
|---|---|
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 |
| Molecular formula | C152H252N44O42 |
| Average molecular mass | approx. 3367.9 g/mol |
| Amount per vial | 5 mg |
| Form | Lyophilized powder, sealed vial |
| HPLC purity | ≥98% |
| Shelf life | 36 months in the sealed vial |
How CJC-1295 (no DAC) is analyzed
A quick arithmetic check separates this peptide from Sermorelin. Asn to Gln and Gly to Ala each add 14 Da, Met to Leu removes 18 Da, and swapping L-Ala for D-Ala changes nothing, so the deconvoluted mass should land about 10 Da above Sermorelin’s. The formula has no sulfur at all, because Leu27 replaces the only methionine; a +16 Da oxidation companion is therefore not an expected impurity, and a sulfur-bearing mass suggests the wrong GRF fragment. Two tyrosines and a phenylalanine allow a 280 nm trace, with purity integrated near 214 nm.
The D-Ala at position 2 is the one stereocenter to watch. Epimerization there gives an L-Ala diastereomer of identical mass, detectable only as a closely eluting peak on a shallow gradient. For CJC-1295 5mg the independent reverse-phase HPLC result is posted on this page, and since the vial label has no batch or lot code, matching the crimp and cap color to that posted result is how a vial is identified.
Research contexts for CJC-1295 (no DAC)
- GHRH receptor binding assays comparing substituted and native GRF(1-29) sequences
- Protease stability comparisons with Sermorelin in cell-free enzyme systems
- Epimer resolution work on peptides containing a single D-residue
- LC-MS identity panels distinguishing GRF(1-29) variants by mass and sulfur content
We supply CJC-1295 (no DAC) for in-vitro experimental and analytical use only, never for use in people or animals.
CJC-1295 (no DAC) questions
Is CJC-1295 without DAC the same as Mod GRF 1-29?
Yes. Both names describe the tetrasubstituted 29-residue amide listed above. The distinction that matters is DAC versus no DAC, not the choice between these two labels.
How can a spectrum tell this product apart from CJC-1295 DAC?
The DAC form is heavier by about 280 Da, near 3647, and elutes at a different retention time. A deconvoluted mass near 3368 indicates the no-DAC peptide.
Why does the formula contain no sulfur?
Native GRF(1-29) has a methionine at position 27. In this analog that position is leucine, so no sulfur-containing residue remains in the chain.
Buying CJC-1295 5mg in the USA
CJC-1295 (no DAC) 5mg is sent from our US stock with parcel tracking, and carriage is free once an order passes $100. Labs building a GRF analog comparison over several runs can ask us about bulk rates. This GRF analog is available only to research institutions, licensed researchers, universities and laboratory R&D purchasers. The structural differences between the two forms are laid out in CJC-1295 vs CJC-1295 DAC: What Is the Difference?
CJC-1295 (no DAC) 5mg is an in-vitro research reagent only: not for human or veterinary use, and sold without preparation or dosing guidance.
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