What CJC-1295 DAC is
CJC-1295 DAC is a 30-residue conjugate built on modified GRF(1-29). Its first 29 positions are the tetrasubstituted GHRH fragment (D-Ala2, Gln8, Ala15, Leu27, C-terminal amide), and a lysine is appended at position 30 whose side-chain amine is acylated with a 3-maleimidopropionyl group. That appended unit is what “DAC”, short for Drug Affinity Complex, refers to: a maleimide ring engineered as a thiol-reactive handle.
The DAC label is not decorative. It changes the molecular mass by roughly 280 Da, the retention time and the chemistry of the product, because a maleimide is an electrophile that the unmodified chain does not have. CJC-1295 without DAC, listed separately in our catalog, is a different material with its own analysis, and a record that says only “CJC-1295” cannot tell the two apart.
CJC-1295 DAC 2mg specification
| Catalog name | CJC-1295 (DAC) |
|---|---|
| Composition | Modified GRF(1-29) amide (D-Ala2, Gln8, Ala15, Leu27) with Lys30 bearing an N-epsilon-3-maleimidopropionyl group |
| Molecular formula | C165H269N47O46 |
| Average molecular mass | approx. 3647.2 g/mol |
| CAS number | 446262-90-4 |
| Amount per vial | 2 mg |
| Form | Lyophilized powder, sealed vial |
| HPLC purity | ≥98% |
| Shelf life | 36 months in the sealed vial |
How CJC-1295 DAC is analyzed
The maleimide defines the impurity profile. In water the five-membered ring can open by hydrolysis, adding 18 Da and producing a maleamic acid species that usually elutes near the parent; any free thiol present can add across the double bond to give an adduct of higher mass. Those two species, together with the epimer that would arise at D-Ala2, are the peaks a method for this compound needs to resolve. The deconvoluted electrospray mass should sit near 3647, well clear of the roughly 3368 expected for the no-DAC chain.
Because the reactive group can change over time in solution, the age and conditions of any analysis are fair questions for this product in particular. Our independent reverse-phase HPLC result for CJC-1295 DAC 2mg is displayed here, and in place of a lot or batch number, each vial’s crimp and cap color identifies which published result it belongs to.
Research contexts for CJC-1295 DAC
- Maleimide-thiol conjugation chemistry with albumin or model thiols in cell-free systems
- Hydrolytic stability studies of maleimide-bearing peptides by LC-MS
- GHRH receptor binding comparisons between conjugated and unconjugated GRF analogs in vitro
- Method development for separating ring-opened and intact maleimide species
CJC-1295 DAC is provided solely for in-vitro laboratory investigation and is not for use in any person or animal.
CJC-1295 DAC questions
What does DAC stand for in CJC-1295 DAC?
Drug Affinity Complex. Chemically it is a lysine at position 30 whose side chain carries a maleimidopropionyl group, the only reactive electrophile in the molecule.
What does a mass 18 Da above 3647 indicate?
Most likely a maleimide ring that has opened by hydrolysis. That species is chemically distinct from the intact conjugate and should appear as its own peak.
Can the DAC and no-DAC forms be substituted for one another?
No. They differ in mass, retention and reactive chemistry, so a result for one says nothing about the other. Check the bracketed suffix on the label against the invoice.
Buying CJC-1295 DAC 2mg in the USA
CJC-1295 DAC 2mg is shipped domestically within the US, tracked from dispatch to delivery, and shipping costs nothing on orders over $100. Reduced pricing applies to larger quantities for groups running repeated conjugation or binding series. CJC-1295 DAC is sold solely to research institutions, licensed researchers, universities and laboratory R&D purchasers. A side-by-side account of both forms is in CJC-1295 vs CJC-1295 DAC: What Is the Difference?
CJC-1295 DAC 2mg is restricted to in-vitro research; it is not for human or veterinary use, and we give no preparation or dosing advice.
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