Kisspeptin 5mg

What Kisspeptin 5mg contains

Kisspeptin is the collective name for peptides processed from the precursor protein encoded by the human KISS1 gene. The longest processed form has 54 residues and is also known as metastin; shorter forms of 14, 13 and 10 residues share its C-terminal stretch, and every one of them ends in an amidated phenylalanine. This listing is cataloged under CAS 374675-21-5, the registry entry for kisspeptin-10, the decapeptide Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2.

Kisspeptin-10 maps to residues 112 to 121 of the KISS1 precursor. Its C-terminal Arg-Phe-amide places it among the RFamide peptides, a label shared with other families that have the same terminal motif but otherwise unrelated sequences. The amide comes from native processing of the precursor rather than from synthetic design, and it is the detail that separates this molecule from a free-acid version of the same ten residues.

Kisspeptin 5mg specification

How Kisspeptin 5mg is analyzed

Because one family name spans peptides from 10 to 54 residues, the observed mass is what settles which kisspeptin a vial holds. The decapeptide should deconvolute near 1302.4; a reading about one dalton higher points to the free C-terminal acid, and a mass in the thousands points to one of the longer forms. A label that reads only “kisspeptin” cannot make that distinction, which is why the registry number and sequence are printed in the table above.

The peptide carries a basic arginine and a free N-terminal amine, so it is normally isolated as a trifluoroacetate or acetate salt, which is why net peptide content and chromatographic purity are distinct numbers. Kisspeptin 5mg is covered by its own independent reverse-phase HPLC record, shown here; the 5 mg vial shows no lot marking, so the crimp and cap color links the vial with that record.

Research contexts for Kisspeptin 5mg

• KISS1R (GPR54) receptor-binding assays in transfected cell lines
• Calcium-mobilization and other second-messenger readouts in KISS1R-expressing cells
• Comparative receptor pharmacology across RFamide peptide families in vitro
• Identity work distinguishing kisspeptin-10, -13, -14 and -54
• Amide versus free-acid discrimination by high-resolution mass spectrometry

Kisspeptin 5mg is a KISS1R reference ligand for work in cell lines and cell-free systems, never for a person or an animal.

Kisspeptin 5mg questions

Which kisspeptin is in this vial?

The listing is registered to kisspeptin-10, the ten-residue amidated form. The observed mass is the confirmation: about 1302 Da for the decapeptide, and far higher for any longer form.

Is kisspeptin the same thing as metastin?

Metastin is an alternative name for kisspeptin-54, the longest processed form. Kisspeptin-10 is its C-terminal ten residues and a much smaller molecule.

What does “RFamide” mean for kisspeptin?

It refers to the C-terminal Arg-Phe-NH2 shared by several peptide families. The term describes that terminal chemistry only and implies no shared sequence beyond those two residues.