What GLP-1/GIP is
GLP-1/GIP is the catalog name for a synthetic dual receptor agonist peptide. In in-vitro receptor pharmacology it is classified against two class B G-protein-coupled receptors at once, the GLP-1 receptor and the GIP receptor, and the slash in the name records exactly that pairing. It is a receptor-nomenclature label, and our nomenclature article sets out what the dual designation means next to single and triple ones.
Chemically it is a 39-residue peptide with a C-terminal amide. It carries two α-aminoisobutyric acid (Aib) residues, a proline-rich C-terminal segment, and one lysine acylated with a C20 diacid through a γ-glutamic acid and ethylene-glycol-based spacer. At about 4813.5 g/mol it is the heaviest member of the receptor-named group, roughly 82 Da above GLP-1/GIP/Glucagon and some 700 Da above the single-receptor GLP-1 product, and it has its own distinct sequence.
GLP-1/GIP 5mg specification
| Catalog name | GLP-1/GIP |
|---|---|
| Receptor designation | Dual receptor agonist peptide (GLP-1 and GIP receptors) |
| Molecular formula | C225H348N48O68 |
| Average molecular mass | approx. 4813.5 g/mol |
| Amount per vial | 5 mg |
| Form | Lyophilized powder, sealed vial |
| HPLC purity | ≥98% |
| Shelf life | 36 months in the sealed vial |
How GLP-1/GIP is analyzed
Two structural features pull the chromatography in different directions. The C20 lipid chain drives strong retention and late elution on reverse-phase columns, while the run of three consecutive prolines near the C-terminus can give slow cis/trans interconversion, which sometimes shows up as a broadened or shouldered main peak rather than a genuine impurity. Wide-pore phases and elevated temperature help with both. Two tyrosines, two phenylalanines and a tryptophan give clear 280 nm absorbance, but purity is still integrated on the peptide bond near 214 nm. In electrospray, look for the 3+, 4+ and 5+ ions near m/z 1605.5, 1204.4 and 963.7.
Relevant impurity classes are des-lipid peptide, tryptophan oxidation, deamidation at either glutamine, loss of the C-terminal amide (a +1 Da free-acid variant) and deletion sequences within the Gly-Pro-Ser tail. Reverse-phase HPLC is run independently on this product and the purity result appears on this page. There is no lot or batch number printed on the vial; a vial is assigned to its published GLP-1/GIP test through the crimp and cap color.
Research contexts for GLP-1/GIP
- Parallel cAMP assays in cell lines expressing either the cloned GLP-1 receptor or the cloned GIP receptor
- Receptor-selectivity and bias profiling of dual agonist peptides against single-receptor comparators
- Proline cis/trans isomer studies by variable-temperature HPLC
- LC-MS characterization of amidated, lipidated long peptides
GLP-1/GIP is provided for in-vitro laboratory research and analytical reference only, never for administration to people or animals.
GLP-1/GIP questions
What does the slash in GLP-1/GIP mean?
It names the two receptors the peptide is classified against. It does not mean the vial is a mixture of two compounds; it holds a single molecule.
Why is there no CAS number in the specification?
We list only identifiers already confirmed for this product’s specification, so the formula and mass are given and no registry number is added.
How does GLP-1/GIP differ from GLP-1/GIP/Glucagon?
They are separate sequences. The triple receptor product has the formula C221H342N46O68 and is about 82 Da lighter, so the two resolve by mass and retention.
Buying GLP-1/GIP 5mg in the USA
GLP-1/GIP 5mg travels by tracked domestic US shipping, free for any order above $100. Laboratories planning repeated receptor-panel work can ask for bulk rates. The dual receptor peptide is supplied to research institutions, licensed researchers, universities and laboratory R&D purchasers only. Our article on GLP-1, GIP and glucagon receptor naming covers how this group of products is labeled.
GLP-1/GIP 5mg is a laboratory research chemical intended for in-vitro studies. Human or veterinary use is excluded, and no preparation or dosing advice accompanies it.
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