GLP-1/GIP/Glucagon – 5mg

What GLP-1/GIP/Glucagon is

GLP-1/GIP/Glucagon is the catalog name of a synthetic triple receptor agonist peptide. Receptor pharmacology describes it by the three class B G-protein-coupled receptors it is characterized against in vitro: the GLP-1 receptor, the GIP receptor and the glucagon receptor. The three names in the title are that classification written out, as our receptor nomenclature article describes, and they refer to one molecule rather than a blend.

It is a long, C-terminally amidated synthetic peptide carrying non-coded α-methyl amino acids, including α-aminoisobutyric acid, and a lysine side chain modified with a long-chain diacid. In size it sits between the other two receptor-named products: about 618 Da heavier than GLP-1 and about 82 Da lighter than GLP-1/GIP. Formula, mass and CAS registry number, 2381089-83-2, are given in the specification below.

GLP-1/GIP/Glucagon 5mg specification

How GLP-1/GIP/Glucagon is analyzed

Because it is close in size and hydrophobicity to the dual receptor product, the two can elute near each other under a fast generic gradient, so a shallower slope through the late part of the run is the practical way to separate them. Mass is the quicker discriminator: the triply, quadruply and quintuply protonated ions of this molecule should appear near m/z 1578.1, 1183.8 and 947.3, each clearly offset from the corresponding GLP-1/GIP ions. Tyrosine and phenylalanine side chains supply absorbance at 280 nm, while purity is read on the amide backbone at about 214 nm.

The α-methyl residues are sterically hindered during synthesis, so deletion peptides missing one of them are a characteristic impurity, alongside the des-lipid species, deamidated forms and the C-terminal free acid. Each product we list, this one included, has its own independent reverse-phase HPLC analysis, and the result is published here. Nothing on the vial carries a lot or batch identifier; instead the crimp and cap color ties a vial to its published analysis.

Research contexts for GLP-1/GIP/Glucagon

• Three-receptor cAMP panels using cell lines expressing the cloned GLP-1, GIP and glucagon receptors
• Relative potency comparisons against the single and dual receptor agonist peptides
• Chromatographic resolution studies of closely related lipidated peptides
• High-resolution mass spectrometry of multiply charged species above 4.5 kDa

Supplied as an analytical and in-vitro reference material; it is not intended for any person or animal.

GLP-1/GIP/Glucagon questions

Is this three peptides in one vial?

No. The three receptor names describe a single peptide classified against three receptors. The vial contains one compound with one formula.

How can it be told apart from GLP-1/GIP by mass spectrometry?

Its average mass is 4,731.33 g/mol against about 4813.5 for the dual product, a gap of roughly 82 Da that separates every charge state cleanly.

Why does the slug say glp3?

It is shorthand in the web address for the three-receptor designation. The full catalog name, GLP-1/GIP/Glucagon, is the identifier that matters.