What Epithalon is
Epithalon, also spelled epitalon, is the catalog name for the synthetic tetrapeptide Ala-Glu-Asp-Gly, abbreviated AEDG. All four residues are standard L-amino acids, the chain ends in a free carboxylic acid, and the free-acid form has the formula C14H22N4O9 with an average mass near 390 g/mol. Of all the coined designations in our short-peptide group it is the one searched for most often, which also makes it the one most often mislabeled elsewhere.
Epithalon should not be confused with epithalamin, a term for a peptide preparation rather than one defined sequence. Inside our own catalog its closest relatives share its opening three residues: Cortagen replaces the terminal glycine with proline, and Cardiogen replaces it with arginine. Livagen uses the same amino acids in a different order behind a lysine. The printed sequence, not the word on the label, is what should be compared.
Epithalon 10mg specification
| Catalog name | Epithalon (epitalon) |
|---|---|
| Sequence | H-Ala-Glu-Asp-Gly-OH (AEDG) |
| Molecular formula | C14H22N4O9 |
| Average mass | approx. 390.35 g/mol |
| CAS number | 307297-39-8 |
| Amount per vial | 10 mg |
| Form | Lyophilized powder in a sealed vial |
| HPLC purity | ≥98% |
| Shelf life | 24 months, sealed vial |
How Epithalon is analyzed
The feature worth knowing in AEDG is the Asp-Gly junction at positions three and four. Aspartate followed by glycine is the motif most prone to cyclizing into a succinimide, which can reopen as isoaspartate: a species with exactly the parent’s elemental composition, so mass spectrometry cannot pick it out by m/z alone. On a reverse-phase trace it tends to run as a small peak hugging the main one, which is why a shallow gradient with a low starting organic fraction matters for this sequence. The succinimide intermediate, when present, reads about 18 Da light. With no aromatic side chain, the peptide is quantified on the amide band in the low-UV region, and a protonated ion just above 390 is the expected identity signal.
Independent reverse-phase HPLC has been run on Epithalon and the result is posted on this product page. Our vials are printed without lot or batch codes; each Epithalon vial is traced to that posted result through its crimp and cap color.
Research contexts for Epithalon
- Isoaspartate and succinimide detection methods using a short Asp-Gly model sequence
- Chromatin-binding and gene-expression assays in cell-culture systems
- Mass-spectrometric discrimination of AEDG from Cortagen (AEDP) and Cardiogen (AEDR)
- Counter-ion and net peptide content studies on low-mass peptides
This material is supplied as a reference reagent for in-vitro laboratory work, with no use in people or animals intended.
Epithalon questions
Are epitalon and epithalon different compounds?
No. They are two transliterations of one name and both refer to AEDG. The sequence and the 390 g/mol mass are the same whichever spelling a supplier prints.
Can a mass spectrum rule out isoaspartate in Epithalon?
Not on its own. Isoaspartyl AEDG has the same composition as the native peptide, so it has to be separated chromatographically, where it usually elutes as a close neighbor of the main peak.
How is Epithalon different from epithalamin?
Epithalon is a single synthetic tetrapeptide with a fixed sequence. Epithalamin names a peptide preparation, so the two terms are not interchangeable.
Buying Epithalon 10mg in the USA
Epithalon 10mg ships domestically within the United States as a tracked parcel, and shipping becomes free once an order passes $100. Groups that need the same material across a longer assay series can request bulk pricing. Epithalon is sold only to research institutions, licensed researchers, universities and laboratory R&D purchasers. Our identity reference, What Is Epithalon? Sequence, Identity and Analytical Profile, sets AEDG beside the other short sequences in the family.
Epithalon 10mg is a reagent for in-vitro and analytical laboratory use only; it is not for human or veterinary use.
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