What Cardiogen is
Cardiogen is a trade name for the tetrapeptide Ala-Glu-Asp-Arg (AEDR), with an average free-acid mass of roughly 489 g/mol, the largest of the short coined-name sequences we carry. Nearly all of that extra mass comes from the C-terminal arginine, which also gives the molecule a permanent positive charge sitting alongside its two acidic side chains.
On paper, Cardiogen can be built from two of its neighbors. Attach arginine to Cartalax (AED) and the result is Cardiogen, about 156 Da heavier. Put an alanine in front of Pinealon (EDR) and it is Cardiogen again, 71 Da heavier. It also shares its first three residues with Epithalon and Cortagen. With so many catalog names overlapping this one sequence, the mass read-out is the quickest way to confirm which compound a vial holds.
Cardiogen 20mg specification
| Catalog name | Cardiogen |
|---|---|
| Sequence | H-Ala-Glu-Asp-Arg-OH (AEDR) |
| Molecular formula | C18H31N7O9 |
| Average mass (free acid) | approx. 489 g/mol |
| Amount per vial | 20 mg |
| Form | Lyophilized peptide powder |
| HPLC purity | ≥98% |
| Shelf life | 36 months, vial unopened |
How Cardiogen is analyzed
AEDR packs strongly acidic and strongly basic character into four residues. On reverse phase its retention depends heavily on the ion-pairing additive, and the arginine side chain can interact with silanol sites to produce peak tailing that should not be mistaken for contamination. Because the arginine and the N-terminal amine can both be protonated, the electrospray spectrum often shows a doubly charged ion around m/z 246 as well as the singly charged ion just above 489, and seeing both is consistent with the correct sequence. No aromatic ring is present, so the chromatogram is integrated in the 214 nm region. Counter-ion bound to the arginine also widens the gap between purity and net peptide content compared with the neutral-to-acidic members of the family.
The purity from Cardiogen’s independent reverse-phase HPLC test is shown on this product page. Since the vials have no lot or batch printing, the crimp and cap color is what connects any vial to that test.
Research contexts for Cardiogen
- Charge-state and fragmentation studies of a short arginine-terminated peptide by ESI-MS/MS
- Ion-pairing and column-chemistry comparisons for mixed acidic–basic peptides
- Protein–peptide binding assays in cell-free systems
- Sequence-identity work across the Ala-Glu-Asp series
All Cardiogen stock is sold for in-vitro laboratory research, and none of it is meant for people or animals.
Cardiogen questions
What does the arginine add to Cardiogen compared with Cartalax?
About 156 Da of mass and a permanent positive charge. Cartalax is purely acidic and retains weakly, while Cardiogen’s arginine makes its retention depend on the ion-pairing additive.
Is retention time enough to confirm Cardiogen’s identity?
No. Retention moves with additive concentration and pH, so it can only support an identification. The mass, near 489 for the free acid, is what confirms the sequence.
Does Cardiogen contain the Pinealon sequence?
Yes. Residues two to four of Cardiogen read Glu-Asp-Arg, which is Pinealon, and the N-terminal alanine is what makes them two different compounds.
Buying Cardiogen 20mg in the USA
Cardiogen 20mg is shipped from US stock with tracking on the parcel, and any order totaling over $100 ships without a shipping fee. Volume pricing is available for groups planning repeated work. Cardiogen can be ordered only by research institutions, licensed researchers, universities and laboratory R&D purchasers. Our reference article What Is Cardiogen? Sequence, Identity and Analytical Profile covers the AEDR sequence and its analysis. Should a third-party laboratory measure purity below our published figure, section 4 of the refund policy sets out what applies.
Research use only: Cardiogen 20mg is a laboratory chemical for in-vitro study, not for human or veterinary use.
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