Pinealon is a commercial designation for the tripeptide Glu-Asp-Arg. This article is an identity reference covering sequence, mass, chromatographic behaviour and verification. It makes no claim about what the compound does and contains no preparation, handling or dosing guidance.
The sequence behind the name
Pinealon is Glu-Asp-Arg, abbreviated EDR: three standard L-amino acids, average free-acid mass of approximately 418 g/mol.
It is the heaviest of the common tripeptide designations in this family, and the reason is the arginine. A guanidinium side chain adds substantial mass and a permanent positive charge across the entire practical pH range, which separates Pinealon analytically from the purely acidic sequences it sits beside in a catalogue.
What the arginine does to the chromatography
Arginine is the most basic residue in the standard set and it stays protonated everywhere. Three consequences follow for anyone reading a Pinealon chromatogram.
Ion pairing carries the retention. Without an ion-pairing additive in the mobile phase, a small peptide with a permanent positive charge and two acidic residues has almost nothing to hold it on a C18 column. Trifluoroacetic acid is usually doing the work, which means the method description is not a formality here — it is the reason the peak is where it is.
Silanol interaction produces tailing. A basic side chain on a silica-based column interacts with residual free silanols. Tailing on a Pinealon peak is frequently a column artefact rather than evidence of an impurity, and reading it as impurity leads to the wrong conclusion about the material.
Retention is pH-sensitive. Small changes in mobile-phase composition move the peak. Two suppliers can therefore publish different retention times for identical material, which is why retention time on its own is never an identity confirmation and has to be paired with a mass.
Detection
EDR contains no tryptophan, tyrosine or phenylalanine, so there is nothing to see at 280 nm. The analysis has to be read at approximately 214 nm on the peptide bond, where the mobile phase absorbs more strongly and baseline quality matters. A purity figure quoted without a wavelength is not evaluable for this compound.
Names in this family are designations, not identifiers
Pinealon sits in the same naming convention as Cartalax (Ala-Glu-Asp), Chonluten (Glu-Asp-Gly), Livagen (Lys-Glu-Asp-Ala) and Epithalon (Ala-Glu-Asp-Gly). None of these names encodes a structure. The sequence on the product page is the identifier; the trade name is a label.
What an analysis should show
Column chemistry and dimensions, mobile phase and gradient with the ion-pairing additive named, detection wavelength, retention time, integrated peak area with a visible integration window, and a mass confirmation consistent with a 418 g/mol free acid. Separately from purity: net peptide content and the declared counter-ion. On a peptide of this size the counter-ion is a meaningful fraction of what is in the vial, and an arginine-containing peptide binds counter-ion readily, so the two numbers can diverge more than a buyer expects.
Confirming identity independently
Search public chemical databases on Glu-Asp-Arg rather than on the word Pinealon. Our product pages carry compound identity links that run that query directly, which is the right way to resolve a name that exists mainly as a commercial designation.
How Pinealon is supplied here
Pinealon 20mg is supplied as a lyophilised powder in a sealed vial, with an independent reverse-phase HPLC analysis published on the product page alongside net peptide content, counter-ion form and vial size. Vials carry no batch or lot numbers; each is matched to its published test by crimp and cap colour.
Frequently asked questions
What is the amino acid sequence of Pinealon?
Glu-Asp-Arg (EDR), a tripeptide of three standard L-amino acids.
What molecular weight should a mass spectrum show?
Approximately 418 g/mol for the free acid. A salt form reads higher, which is why the counter-ion has to be declared alongside the mass.
Is Pinealon the same as Epithalon?
No. Epithalon is the tetrapeptide Ala-Glu-Asp-Gly at about 390 g/mol. Pinealon is the tripeptide Glu-Asp-Arg at about 418 g/mol. Different sequences, different masses, different chromatographic behaviour, and a certificate for one says nothing about the other.
Why does the Pinealon peak tail on my chromatogram?
Usually because the arginine side chain is interacting with residual silanols on a silica-based column. It is a column-and-mobile-phase effect more often than a purity effect. Check what additive was used before treating tailing as an impurity.
Do Pinealon vials carry a lot number?
No. There are no batch or lot identifiers printed on the label. Vials are matched to their published test by crimp and cap colour.
Research use only. All products supplied by Battle Born Peptides are laboratory reference materials for in-vitro research and analytical use by qualified professionals. They are not drugs, foods, dietary supplements, cosmetics or medical devices; they are not approved by the FDA or any other regulator for use in humans or animals; and they are not intended to diagnose, treat, cure, mitigate or prevent any disease, or to affect the structure or any function of the body of humans or animals. Nothing in this article is preparation, handling or dosing guidance. See our full research-use terms.