What Hexarelin is
Hexarelin is the synthetic hexapeptide amide His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2. Two positions are non-standard: position 2 is D-2-methyl-tryptophan, a D-configured tryptophan with an extra methyl on carbon 2 of the indole ring, and position 5 is D-phenylalanine. Histidine, alanine, the second tryptophan and lysine are ordinary L-residues. The compound has also been cataloged in the literature as examorelin, but the sequence is the identifier that counts.
Its nearest relative is GHRP-6, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2. The two differ only by that single ring methyl, about 14 Da, which a trade name will not reveal. Ipamorelin, the other short ghrelin-receptor ligand in our catalog, is a different design altogether, with five residues, Aib and a naphthylalanine in place of the indole rings.
Hexarelin 2mg specification
| Catalog name | Hexarelin |
|---|---|
| Sequence | His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Molecular formula | C47H58N12O6 |
| Average molecular mass | approx. 887.0 g/mol |
| CAS number | 140703-51-1 |
| Amount per vial | 2 mg |
| Form | Lyophilized powder, sealed vial |
| HPLC purity | ≥98% |
| Shelf life | 36 months in the sealed vial |
How Hexarelin is analyzed
Two indole side chains give Hexarelin a strong 280 nm absorbance, so it can be followed at two wavelengths, with purity still integrated near 214 nm because impurities that have lost an aromatic residue are undercounted at 280 nm. The indoles and the phenyl ring make it retain well on C18 despite the basic histidine, lysine and free N-terminus, and it elutes clearly away from the solvent front. Tryptophan-rich sequences are also prone to oxidative modification of the indole, which shows up as small species of higher mass beside the main peak. In electrospray, expect both singly and doubly charged ions corresponding to a neutral mass near 887.
A mass near 873 instead of 887 points to the unmethylated relative rather than Hexarelin, while a diastereomer at position 2 or 5 has the correct mass and can only be revealed chromatographically. The Hexarelin 2mg result from independent reverse-phase HPLC is published here; the vials are not lot- or batch-coded, so the crimp and cap color is what matches a vial to its published test.
Research contexts for Hexarelin
- GHS-R1a binding and competition assays in transfected cell lines or membrane preparations
- Structure-activity comparisons of 2-methyl-Trp versus D-Trp at position 2 alongside GHRP-6
- Resolution of D/L diastereomers in short tryptophan-rich peptides
- Characterization of indole oxidation products by LC-MS
Hexarelin 2mg is sold as a research chemical for in-vitro studies and is not intended for use in humans or animals.
Hexarelin questions
Is Hexarelin the same as GHRP-6?
No. The sequences match except for the methyl group on the position-2 indole ring, which Hexarelin has and GHRP-6 lacks. The two differ by about 14 Da and separate on reverse-phase HPLC.
What mass should the spectrum show for Hexarelin?
A neutral mass of about 887.0, usually observed as the [M+H]+ ion near m/z 888 and a doubly charged ion near m/z 444.5.
Why does Hexarelin absorb strongly at 280 nm?
It carries two tryptophan-derived indole rings, which are strong chromophores at 280 nm, as well as a phenylalanine.
Buying Hexarelin 2mg in the USA
Hexarelin 2mg is fulfilled from within the US and every shipment is tracked; orders over $100 carry no shipping charge. For laboratories that use Hexarelin repeatedly as a comparison standard, bulk pricing is available on request. Only research institutions, licensed researchers, universities and laboratory R&D purchasers may buy it. The full identity profile is in What Is Hexarelin? Sequence, Identity and Analytical Profile.
Hexarelin 2mg is for in-vitro research use only: not for human or veterinary use, and supplied without any preparation or dosing guidance.
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