Tesamorelin 10mg

What Tesamorelin 10mg contains

Each vial holds 10 mg of Tesamorelin, a 44-residue peptide amide whose chain reproduces human GHRH(1-44) residue for residue, capped at the N-terminus with a trans-3-hexenoyl group. At more than 5 kDa it is the largest member of our GHRH-derived group and one of the longest chemically synthesized peptides in the catalog, which shapes almost everything about how it is characterized.

Within the GHRH shelf the members separate cleanly by size. Sermorelin and CJC-1295 are 29-residue fragments near 3.4 kDa, CJC-1295 DAC reaches about 3.6 kDa with its extra lysine conjugate, and Tesamorelin alone carries the C-terminal stretch from residue 30 to 44, Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu. That tail is why a mass reading in the low 3000s can never belong to this product.

Tesamorelin 10mg specification

How Tesamorelin 10mg is analyzed

A 44-step solid-phase synthesis offers 44 chances for an incomplete coupling, so single-residue deletion sequences are the characteristic impurity class, and for a chain this long they can elute almost on top of the main peak. Two asparagines (positions 8 and 35) and seven glutamines add deamidation, a +1 Da change that low-resolution instruments barely register, while Asp3 and Asp25 are candidates for isomerization. Wide-pore C4 or C18 packings give better peak shape than small-molecule columns, and a shallow gradient through the elution window is what separates these near neighbors.

Six arginines and two lysines give the molecule many protonation sites, so it carries a substantial counter-ion load and, in electrospray, shows a ladder of charge states, for example near m/z 1028 (5+), 857 (6+) and 735 (7+), that deconvolutes to about 5136. We publish the independent reverse-phase HPLC result for Tesamorelin 10mg on this page; vials have no lot or batch printing, and a vial’s crimp and cap color is how you find the result that applies to it.

Research contexts for Tesamorelin 10mg

• Intact-mass and charge-state deconvolution method development for peptides above 5 kDa
• Deletion-sequence and deamidation profiling of long synthetic peptides by LC-MS
• Full-length versus truncated GHRH analog comparisons in receptor-binding assays
• Column and gradient selection studies for late-eluting, highly basic peptides

We provide this vial as a reagent for in-vitro study only; it is not meant for people or animals.

Tesamorelin 10mg questions

Why does the Tesamorelin mass spectrum show several peaks?

Its many basic side chains pick up different numbers of protons during electrospray, producing a series of charge states. Deconvolution collapses that series into one neutral mass for comparison with about 5136.

How does Tesamorelin differ from CJC-1295?

CJC-1295 is a substituted 29-residue fragment with a free N-terminus; Tesamorelin keeps the native sequence at all 44 positions and adds an N-terminal acyl cap, making it roughly 1.8 kDa heavier.

Why is Tesamorelin also offered in a 10 mg vial?

The larger vial suits labs that run the same reference material through long method-development or comparison series and prefer a single published HPLC result behind all of it.